| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Isaac | city | Virginia | United States | 36.69 | -76.97 | 65 | |
| Isaacs Colonia | city | Texas | United States | 26.26 | -98.09 | 82 | |
| Isaacs Corner | city | Rhode Island | United States | 41.16 | -71.58 | 98 | |
| Isaar | city | Wisconsin | United States | 44.57 | -88.28 | 830 | |
| Isaban | city | West Virginia | United States | 37.53 | -81.89 | 1204 | |
| Isabel | city | Illinois | United States | 39.66 | -87.95 | 830 | |
| Isabel | city | Kansas | United States | 37.47 | -98.55 | 1820 | |
| Isabel | city | Louisiana | United States | 30.67 | -90.00 | 91 | |
| Isabel | city | North Dakota | United States | 48.06 | -99.65 | 1669 | |
| Isabel | city | South Dakota | United States | 45.39 | -101.43 | 2509 | |
| Isabel Estates | city | Florida | United States | 27.97 | -82.13 | 98 | |
| Isabel Josefa | city | Puerto Rico | United States | 18.10 | -67.13 | 45 | |
| Isabel Segunda | city | Puerto Rico | United States | 18.15 | -65.44 | 131 | |
| Isabela | city | Puerto Rico | United States | 18.50 | -67.02 | 200 | |
| Isabela Zona Urbana | city | Puerto Rico | United States | 18.50 | -67.02 | 200 | |
| Isabell (historical) | city | Mississippi | United States | 30.94 | -88.62 | 147 | |
| Isabella | city | Alabama | United States | 32.83 | -86.79 | 400 | |
| Isabella | city | Georgia | United States | 31.57 | -83.85 | 830 | |
| Isabella | city | Minnesota | United States | 47.62 | -91.35 | 1952 | |
| Isabella | city | Missouri | United States | 36.58 | -92.61 | 898 | |
| Isabella | city | Oklahoma | United States | 36.24 | -98.34 | 1253 | |
| Isabella | city | Pennsylvania | United States | 39.94 | -79.94 | 1092 | |
| Isabella | city | Pennsylvania | United States | 40.12 | -75.84 | 830 | |
| Isabella | city | Tennessee | United States | 35.03 | -84.36 | 1699 | |
| Isabella | city | Michigan | United States | 45.90 | -86.61 | 830 | |
| Isabella (historical) | city | California | United States | 35.66 | -118.46 | 2660 | |
| Isabella Heights | city | Georgia | United States | 31.57 | -84.12 | 226 | |
| Isabella Landing | city | Idaho | United States | 46.85 | -115.63 | 1801 | |
| Isabella Mobile Home Park | city | Michigan | United States | 43.60 | -84.75 | 830 | |
| Isabellas Place Mobile Home Park | city | Florida | United States | 29.62 | -81.65 | 22 | |
| Isadora | city | Missouri | United States | 40.53 | -94.52 | 1089 | |
| Isadore | city | Michigan | United States | 44.88 | -85.77 | 830 | |
| Isaiah (historical) | city | California | United States | 39.72 | -121.44 | 2001 | |
| Isanti | city | Minnesota | United States | 45.49 | -93.25 | 935 | |
| Isanti Estates | city | Minnesota | United States | 45.45 | -93.23 | 928 | |
| Isaqueena Park | city | South Carolina | United States | 34.86 | -82.37 | 925 | |
| Isaqueena Village | city | South Carolina | United States | 34.71 | -82.79 | 889 |