| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| McBee | city | South Carolina | United States | 34.47 | -80.26 | 830 | |
| McCabe (historical) | city | South Carolina | United States | 34.10 | -80.33 | 177 | |
| McCalls Corner | city | South Carolina | United States | 32.73 | -79.97 | 6 | |
| McCalls Crossroads (historical) | city | South Carolina | United States | 34.27 | -79.70 | 88 | |
| McCaskill | city | South Carolina | United States | 34.12 | -80.70 | 147 | |
| McClellanville | city | South Carolina | United States | 33.09 | -79.46 | 9 | |
| McColl | city | South Carolina | United States | 34.67 | -79.55 | 160 | |
| McCombs | city | South Carolina | United States | 34.18 | -82.22 | 830 | |
| McConnells | city | South Carolina | United States | 34.87 | -81.23 | 830 | |
| McCormick | city | South Carolina | United States | 33.91 | -82.29 | 830 | |
| McCormick Crossroads | city | South Carolina | United States | 34.50 | -79.48 | 150 | |
| McCoys Crossroads | city | South Carolina | United States | 34.38 | -80.25 | 318 | |
| McCrearys Quarter (historical) | city | South Carolina | United States | 34.06 | -80.62 | 121 | |
| McCutchen (historical) | city | South Carolina | United States | 34.18 | -80.29 | 232 | |
| McCutchens Crossroads | city | South Carolina | United States | 34.15 | -80.23 | 180 | |
| McDaniel Heights | city | South Carolina | United States | 34.82 | -82.62 | 1000 | |
| McDonalds | city | South Carolina | United States | 34.62 | -79.54 | 180 | |
| McElveen | city | South Carolina | United States | 34.16 | -79.74 | 78 | |
| McGee Acres | city | South Carolina | United States | 34.56 | -82.63 | 849 | |
| McGreegor Downs | city | South Carolina | United States | 35.05 | -81.90 | 830 | |
| McInnis (historical) | city | South Carolina | United States | 34.55 | -79.51 | 160 | |
| McKellar Farms | city | South Carolina | United States | 34.19 | -82.10 | 830 | |
| McKelvey Crossroads | city | South Carolina | United States | 34.61 | -82.37 | 912 | |
| McKennon | city | South Carolina | United States | 34.55 | -80.13 | 400 | |
| McKenzie Crossroads | city | South Carolina | United States | 33.91 | -79.91 | 111 | |
| McKeown | city | South Carolina | United States | 34.62 | -81.18 | 830 | |
| McLaughlin Crossroads | city | South Carolina | United States | 34.22 | -80.06 | 170 | |
| McNeils (historical) | city | South Carolina | United States | 34.67 | -79.94 | 98 | |
| McPhersonville | city | South Carolina | United States | 32.69 | -80.92 | 55 | |
| McQueen Crossroads | city | South Carolina | United States | 34.07 | -79.14 | 62 | |
| McSwain Gardens | city | South Carolina | United States | 34.88 | -82.33 | 951 |