| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sparkleberry Landing | city | North Carolina | United States | 34.48 | -78.21 | 42 | |
| Sparta | city | North Carolina | United States | 36.51 | -81.12 | 2864 | |
| Spear | city | North Carolina | United States | 36.02 | -82.02 | 2864 | |
| Speed | city | North Carolina | United States | 35.97 | -77.45 | 68 | |
| Speedwell | city | North Carolina | United States | 35.28 | -83.19 | 2509 | |
| Speight | city | North Carolina | United States | 35.60 | -77.34 | 26 | |
| Speight Forest | city | North Carolina | United States | 35.90 | -77.57 | 52 | |
| Speights Bridge | city | North Carolina | United States | 35.56 | -77.74 | 49 | |
| Spencer | city | North Carolina | United States | 35.69 | -80.43 | 830 | |
| Spencer Heights | city | North Carolina | United States | 35.86 | -81.63 | 1099 | |
| Spencer Mountain | city | North Carolina | United States | 35.31 | -81.11 | 830 | |
| Spences Corner | city | North Carolina | United States | 36.35 | -76.20 | 9 | |
| Spicewood | city | North Carolina | United States | 36.13 | -79.79 | 830 | |
| Spicewood Acres | city | North Carolina | United States | 35.18 | -80.70 | 830 | |
| Spies | city | North Carolina | United States | 35.42 | -79.67 | 830 | |
| Spillcorn | city | North Carolina | United States | 35.95 | -82.65 | 2864 | |
| Spilona | city | North Carolina | United States | 35.49 | -78.47 | 249 | |
| Spindale | city | North Carolina | United States | 35.36 | -81.93 | 1079 | |
| Spiveys Corner | city | North Carolina | United States | 35.20 | -78.49 | 200 | |
| Spooners Creek East Harbor | city | North Carolina | United States | 34.73 | -76.80 | 0 | |
| Spooners Creek Harbor | city | North Carolina | United States | 34.73 | -76.81 | 0 | |
| Spooners Creek North | city | North Carolina | United States | 34.73 | -76.81 | 3 | |
| Sportsmans Village | city | North Carolina | United States | 34.97 | -76.59 | 0 | |
| Spot | city | North Carolina | United States | 36.12 | -75.82 | 3 | |
| Spout Springs | city | North Carolina | United States | 35.27 | -79.06 | 351 | |
| Sprangler Apartments | city | North Carolina | United States | 35.29 | -81.53 | 830 | |
| Spray (historical) | city | North Carolina | United States | 36.52 | -79.76 | 830 | |
| Spring Creek | city | North Carolina | United States | 35.32 | -76.66 | 3 | |
| Spring Creek | city | North Carolina | United States | 35.80 | -82.85 | 2509 | |
| Spring Garden | city | North Carolina | United States | 35.20 | -77.16 | 29 | |
| Spring Hill | city | North Carolina | United States | 36.21 | -77.43 | 88 | |
| Spring Hill | city | North Carolina | United States | 35.41 | -77.97 | 98 | |
| Spring Hill | city | North Carolina | United States | 34.19 | -78.07 | 22 | |
| Spring Hill | city | North Carolina | United States | 34.88 | -79.38 | 226 | |
| Spring Hill | city | North Carolina | United States | 35.49 | -82.85 | 3349 | |
| Spring Hope | city | North Carolina | United States | 35.20 | -76.98 | 29 | |
| Spring Hope | city | North Carolina | United States | 35.30 | -78.04 | 157 | |
| Spring Hope | city | North Carolina | United States | 35.95 | -78.11 | 200 | |
| Spring Lake | city | North Carolina | United States | 35.76 | -77.92 | 118 | |
| Spring Lake | city | North Carolina | United States | 35.31 | -80.87 | 830 | |
| Spring Lake | city | North Carolina | United States | 35.17 | -78.97 | 298 | |
| Spring Oaks Mobile Home Estates | city | North Carolina | United States | 34.11 | -77.90 | 26 | |
| Spring Time | city | North Carolina | United States | 35.60 | -82.52 | 2509 | |
| Spring Valley | city | North Carolina | United States | 35.92 | -79.08 | 830 | |
| Spring Valley | city | North Carolina | United States | 36.12 | -79.47 | 830 | |
| Spring Valley | city | North Carolina | United States | 36.04 | -79.82 | 830 | |
| Spring Valley | city | North Carolina | United States | 35.14 | -80.85 | 830 | |
| Spring Valley | city | North Carolina | United States | 36.04 | -78.98 | 830 | |
| Springcrest Meadows | city | North Carolina | United States | 36.18 | -79.06 | 830 | |
| Springdale | city | North Carolina | United States | 35.29 | -81.14 | 830 | |
| Springdale (historical) | city | North Carolina | United States | 35.44 | -82.81 | 2874 | |
| Springdale Acres | city | North Carolina | United States | 34.74 | -77.48 | 55 | |
| Springfield | city | North Carolina | United States | 35.17 | -80.90 | 830 | |
| Springfield | city | North Carolina | United States | 34.78 | -79.53 | 183 | |
| Springfield | city | North Carolina | United States | 35.93 | -79.99 | 830 | |
| Springfield (historical) | city | North Carolina | United States | 36.36 | -81.19 | 1669 | |
| Springhaven | city | North Carolina | United States | 35.37 | -80.16 | 830 | |
| Springsville (historical) | city | North Carolina | United States | 35.46 | -80.71 | 830 | |
| Springwood | city | North Carolina | United States | 35.27 | -81.06 | 830 | |
| Spruce Pine | city | North Carolina | United States | 35.92 | -82.06 | 2565 | |
| Spurgeon (historical) | city | North Carolina | United States | 36.09 | -81.03 | 1181 |